BAIT
RUFY1
RABIP4, ZFYVE12
RUN and FYVE domain containing 1
GO Process (0)
GO Function (1)
GO Component (3)
Gene Ontology Molecular Function
Homo sapiens
PREY
STRAP
MAWD, PT-WD, UNRIP
serine/threonine kinase receptor associated protein
GO Process (8)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- maintenance of gastrointestinal epithelium [IMP]
- negative regulation of epithelial cell migration [IMP]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of epithelial to mesenchymal transition [IMP]
- negative regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- negative regulation of transforming growth factor beta receptor signaling pathway [IMP, TAS]
- spliceosomal snRNP assembly [IDA]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.
Arl8b, an Arf-like GTP-binding protein, regulates cargo trafficking and positioning of lysosomes. However, it is unknown whether Arl8b regulates lysosomal cargo sorting. Here, we report that Arl8b binds to the Rab4 and Rab14 interaction partner, RUN and FYVE domain-containing protein (RUFY) 1, a known regulator of cargo sorting from recycling endosomes. Arl8b determines RUFY1 endosomal localization through regulating its interaction ... [more]
J Cell Biol Jan. 02, 2023; 222(1); [Pubmed: 36282215]
Throughput
- High Throughput
Curated By
- BioGRID