ATAD1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
UBE2L3
Gene Ontology Biological Process
- cell cycle phase transition [ISO]
- cell proliferation [ISO]
- cellular response to glucocorticoid stimulus [ISO]
- cellular response to steroid hormone stimulus [ISO]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of ubiquitin-protein transferase activity [ISO]
- protein K11-linked ubiquitination [ISO]
- protein polyubiquitination [ISO]
- protein ubiquitination [IDA, ISO]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- regulation of transcription, DNA-templated [ISO]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle.
Maintenance of desmin intermediate filaments (IF) is vital for muscle plasticity and function, and their perturbed integrity due to accelerated loss or aggregation causes atrophy and myopathies. Calpain-1-mediated disassembly of ubiquitinated desmin IF is a prerequisite for desmin loss, myofibril breakdown, and atrophy. Because calpain-1 does not harbor a bona fide ubiquitin-binding domain, the precise mechanism for desmin IF disassembly ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID