ATAD1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CUL4A
Gene Ontology Biological Process
- hemopoiesis [IMP]
- negative regulation of granulocyte differentiation [IDA]
- positive regulation of G1/S transition of mitotic cell cycle [IMP]
- positive regulation of cell proliferation [IDA]
- positive regulation of protein catabolic process [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- regulation of DNA damage checkpoint [IMP]
- regulation of nucleotide-excision repair [IMP]
- regulation of protein metabolic process [IMP]
- somatic stem cell maintenance [IMP]
- ubiquitin-dependent protein catabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle.
Maintenance of desmin intermediate filaments (IF) is vital for muscle plasticity and function, and their perturbed integrity due to accelerated loss or aggregation causes atrophy and myopathies. Calpain-1-mediated disassembly of ubiquitinated desmin IF is a prerequisite for desmin loss, myofibril breakdown, and atrophy. Because calpain-1 does not harbor a bona fide ubiquitin-binding domain, the precise mechanism for desmin IF disassembly ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID