BAIT
TRIM33
ECTO, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA
tripartite motif containing 33
GO Process (9)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- gene expression [TAS]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transcription, DNA-templated [NAS]
- protein ubiquitination [IDA]
- regulation of transforming growth factor beta receptor signaling pathway [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
S100A9
60B8AG, CAGB, CFAG, CGLB, L1AG, LIAG, MAC387, MIF, MRP14, NIF, P14
S100 calcium binding protein A9
GO Process (18)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- autophagy [IDA]
- cell-cell signaling [TAS]
- chemokine production [TAS]
- cytokine production [TAS]
- defense response to bacterium [TAS]
- defense response to fungus [TAS]
- inflammatory response [TAS]
- leukocyte migration involved in inflammatory response [IDA]
- neutrophil aggregation [IDA]
- neutrophil chemotaxis [IDA]
- positive regulation of NF-kappaB transcription factor activity [TAS]
- positive regulation of cell growth [TAS]
- positive regulation of inflammatory response [IDA]
- positive regulation of intrinsic apoptotic signaling pathway [IDA]
- regulation of cytoskeleton organization [TAS]
- sequestering of zinc ion [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TIF1? inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.
The molecular underpinnings of lung adenocarcinoma (LUAD) metastasis remain poorly defined. Here, using human LUAD cell lines, we find that transcriptional intermediary factor 1 ? (TIF1?) binds to TATA box binding protein (TBP) in competition with TBP-associated factor 15 (TAF15) and impedes TAF15/TBP-mediated interleukin 6 (IL-6) transactivation. TIF1? modifies TAF15 through multi-mono-ubiquitylation and drives nuclear export of TAF15. Functionally, TAF15 ... [more]
Cell Rep Oct. 18, 2022; 41(3);111513 [Pubmed: 36261009]
Throughput
- High Throughput
Curated By
- BioGRID