BAIT

RPN2

RIBIIR, RPN-II, RPNII, SWP1, RP3-343K2.2

ribophorin II

GO Process (7)

GO Function (1)

GO Component (5)

Gene Ontology Biological Process

SRP-dependent cotranslational protein targeting to membrane [TAS]

cellular protein metabolic process [TAS]

cellular protein modification process [TAS]

gene expression [TAS]

post-translational protein modification [TAS]

protein N-linked glycosylation via asparagine [NAS, TAS]

translation [TAS]

Gene Ontology Molecular Function

dolichyl-diphosphooligosaccharide-protein glycotransferase activity [NAS]

Gene Ontology Cellular Component

endoplasmic reticulum [IDA]

endoplasmic reticulum membrane [TAS]

oligosaccharyltransferase complex [TAS]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

PYCR1

ARCL2B, ARCL3B, P5C, P5CR, PIG45, PP222, PRO3, PYCR

pyrroline-5-carboxylate reductase 1

GO Process (7)

GO Function (3)

GO Component (2)

Gene Ontology Biological Process

cellular amino acid biosynthetic process [TAS]

cellular nitrogen compound metabolic process [TAS]

cellular response to oxidative stress [IMP]

negative regulation of hydrogen peroxide-induced cell death [IMP]

proline biosynthetic process [IDA]

regulation of mitochondrial membrane potential [IMP]

small molecule metabolic process [TAS]

Gene Ontology Molecular Function

identical protein binding [IPI]
protein binding [IPI]
pyrroline-5-carboxylate reductase activity [IDA, TAS]

Gene Ontology Cellular Component

mitochondrial matrix [TAS]

mitochondrion [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.

Li B, Zhao R, Qiu W, Pan Z, Zhao S, Qi Y, Qiu J, Zhang S, Guo Q, Fan Y, Xu H, Li M, Li G, Xue H

Background: Glioblastoma (GBM) is the most common primary brain malignancy and has high aggressiveness and a poor prognosis. N6-methyladenosine (m6A) represents the most prevalent methylation modification of lncRNAs and has been shown to play important roles in the pathophysiological processes of tumors. However, the distribution and function of m6A modifications in lncRNAs in GBM tissues have not been fully revealed. ... [more]

Theranostics Sep. 29, 2022; 12(14);6363-6379 [Pubmed: 36168628]

Throughput

High Throughput

Curated By

BioGRID