YWHAZ
Gene Ontology Biological Process
- Golgi reassembly [IMP]
- RNA metabolic process [TAS]
- apoptotic process [TAS]
- blood coagulation [TAS]
- establishment of Golgi localization [IMP]
- gene expression [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- mRNA metabolic process [TAS]
- membrane organization [TAS]
- negative regulation of apoptotic process [TAS]
- platelet activation [TAS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TH
Gene Ontology Biological Process
- anatomical structure morphogenesis [TAS]
- catecholamine biosynthetic process [TAS]
- cellular nitrogen compound metabolic process [TAS]
- dopamine biosynthetic process [IDA]
- dopamine biosynthetic process from tyrosine [NAS]
- embryonic camera-type eye morphogenesis [ISS]
- epinephrine biosynthetic process [IDA]
- eye photoreceptor cell development [ISS]
- heart development [ISS]
- heart morphogenesis [NAS]
- learning [ISS]
- locomotory behavior [ISS]
- memory [ISS]
- norepinephrine biosynthetic process [IDA]
- organ morphogenesis [ISS]
- pigmentation [TAS]
- regulation of heart contraction [ISS]
- response to ethanol [IDA]
- response to hypoxia [IDA]
- small molecule metabolic process [TAS]
- synaptic transmission, dopaminergic [ISS]
- visual perception [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Cysteine Modification by Ebselen Reduces the Stability and Cellular Levels of 14-3-3 Proteins.
The 14-3-3 proteins constitute a family of adaptor proteins with many binding partners and biological functions, and they are considered promising drug targets in cancer and neuropsychiatry. By screening 1280 small-molecule drugs using differential scanning fluorimetry (DSF), we found 15 compounds that decreased the thermal stability of 14-3-3? Among these compounds, ebselen was identified as a covalent, destabilizing ligand of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID