BAIT
TRIM67
TNL
tripartite motif containing 67
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
FIS1
TTC11, CGI-135
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GO Process (18)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- calcium-mediated signaling using intracellular calcium source [IMP]
- mitochondrial fission [IDA, IMP]
- mitochondrial fragmentation involved in apoptotic process [IDA, IMP]
- mitochondrial fusion [IMP]
- mitochondrion degradation [IDA]
- mitochondrion morphogenesis [IMP]
- negative regulation of endoplasmic reticulum calcium ion concentration [IMP]
- peroxisome fission [IDA, IMP]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of intrinsic apoptotic signaling pathway [IMP]
- positive regulation of mitochondrial calcium ion concentration [IMP]
- positive regulation of mitochondrial fission [IDA]
- positive regulation of protein targeting to membrane [IDA]
- protein homooligomerization [IMP]
- protein targeting to mitochondrion [IMP]
- regulation of mitochondrion organization [IMP]
- release of cytochrome c from mitochondria [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing.
IDH mutant gliomas are grouped into astrocytomas or oligodendrogliomas depending on the co-deletion of chromosome arms 1p and 19q. Although the genomic alterations of IDH mutant gliomas have been well described, transcriptional changes unique to either tumor type have not been fully understood. Here, we identify Tripartite Motif Containing 67 (TRIM67), an E3 ubiquitin ligase with essential roles during neuronal ... [more]
Neuro Oncol Oct. 10, 2022; (); [Pubmed: 36215168]
Throughput
- High Throughput
Curated By
- BioGRID