BAIT
TRIM67
TNL
tripartite motif containing 67
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
SOD2
IPOB, MNSOD, MVCD6, RP1-56L9.2
superoxide dismutase 2, mitochondrial
GO Process (13)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- age-dependent response to reactive oxygen species [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of neuron apoptotic process [IGI]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IMP]
- oxygen homeostasis [IMP]
- protein homotetramerization [IPI]
- regulation of blood pressure [ISS]
- regulation of transcription from RNA polymerase II promoter [IMP]
- release of cytochrome c from mitochondria [ISS]
- removal of superoxide radicals [IMP]
- response to superoxide [IMP]
- superoxide metabolic process [IDA]
- vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing.
IDH mutant gliomas are grouped into astrocytomas or oligodendrogliomas depending on the co-deletion of chromosome arms 1p and 19q. Although the genomic alterations of IDH mutant gliomas have been well described, transcriptional changes unique to either tumor type have not been fully understood. Here, we identify Tripartite Motif Containing 67 (TRIM67), an E3 ubiquitin ligase with essential roles during neuronal ... [more]
Neuro Oncol Oct. 10, 2022; (); [Pubmed: 36215168]
Throughput
- High Throughput
Curated By
- BioGRID