BAIT
TRIM67
TNL
tripartite motif containing 67
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
DICER1
DCR1, Dicer, Dicer1e, HERNA, K12H4.8-LIKE, MNG1, RMSE2
dicer 1, ribonuclease type III
GO Process (15)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- RNA phosphodiester bond hydrolysis [IDA]
- RNA phosphodiester bond hydrolysis, endonucleolytic [IDA, IMP]
- conversion of ds siRNA to ss siRNA [IMP]
- gene expression [TAS]
- negative regulation of Schwann cell proliferation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- nerve development [ISS]
- neuron projection morphogenesis [ISS]
- peripheral nervous system myelin formation [ISS]
- positive regulation of Schwann cell differentiation [ISS]
- positive regulation of myelination [ISS]
- pre-miRNA processing [IDA]
- production of miRNAs involved in gene silencing by miRNA [ISS]
- production of siRNA involved in RNA interference [IDA]
- targeting of mRNA for destruction involved in RNA interference [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing.
IDH mutant gliomas are grouped into astrocytomas or oligodendrogliomas depending on the co-deletion of chromosome arms 1p and 19q. Although the genomic alterations of IDH mutant gliomas have been well described, transcriptional changes unique to either tumor type have not been fully understood. Here, we identify Tripartite Motif Containing 67 (TRIM67), an E3 ubiquitin ligase with essential roles during neuronal ... [more]
Neuro Oncol Oct. 10, 2022; (); [Pubmed: 36215168]
Throughput
- High Throughput
Curated By
- BioGRID