BAIT
STIP1
HEL-S-94n, HOP, IEF-SSP-3521, P60, STI1, STI1L
stress-induced phosphoprotein 1
GO Process (1)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ACADM
ACAD1, MCAD, MCADH, RP4-682C21.1
acyl-CoA dehydrogenase, C-4 to C-12 straight chain
GO Process (9)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- carnitine biosynthetic process [IMP]
- carnitine metabolic process, CoA-linked [IMP]
- cellular lipid metabolic process [TAS]
- fatty acid beta-oxidation [IMP, TAS]
- fatty acid beta-oxidation using acyl-CoA dehydrogenase [IDA, IMP]
- medium-chain fatty acid catabolic process [IDA]
- medium-chain fatty acid metabolic process [IDA]
- oxidation-reduction process [IDA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.
Hop/Stip1/Sti1 is thought to be essential as a co-chaperone to facilitate substrate transfer between the Hsp70 and Hsp90 molecular chaperones. Despite this proposed key function for protein folding and maturation, it is not essential in a number of eukaryotes and bacteria lack an ortholog. We set out to identify and to characterize its eukaryote-specific function. Human cell lines and the ... [more]
Nat Commun Nov. 25, 2020; 11(1);5975 [Pubmed: 33239621]
Throughput
- High Throughput
Curated By
- BioGRID