BAIT

STIP1

HEL-S-94n, HOP, IEF-SSP-3521, P60, STI1, STI1L

stress-induced phosphoprotein 1

GO Process (1)

GO Function (2)

GO Component (2)

Gene Ontology Biological Process

response to stress [TAS]

Gene Ontology Molecular Function

poly(A) RNA binding [IDA]
protein binding [IPI]

Gene Ontology Cellular Component

Golgi apparatus [TAS]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

BCAP31

6C6-AG, BAP31, CDM, DDCH, DXS1357E

B-cell receptor-associated protein 31

GO Process (9)

GO Function (1)

GO Component (7)

Gene Ontology Biological Process

antigen processing and presentation of peptide antigen via MHC class I [TAS]

apoptotic process [TAS]

calcium-mediated signaling using intracellular calcium source [IMP]

cellular component disassembly involved in execution phase of apoptosis [TAS]

negative regulation of endoplasmic reticulum calcium ion concentration [IMP]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]

positive regulation of cytosolic calcium ion concentration [IMP]

positive regulation of intrinsic apoptotic signaling pathway [IMP]

positive regulation of mitochondrial calcium ion concentration [IMP]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

endoplasmic reticulum [IDA]

endoplasmic reticulum membrane [TAS]

integral component of lumenal side of endoplasmic reticulum membrane [TAS]

integral component of plasma membrane [IDA]

lipid particle [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

Bhattacharya K, Weidenauer L, Luengo TM, Pieters EC, Echeverria PC, Bernasconi L, Wider D, Sadian Y, Koopman MB, Villemin M, Bauer C, Ruediger SGD, Quadroni M, Picard D

Hop/Stip1/Sti1 is thought to be essential as a co-chaperone to facilitate substrate transfer between the Hsp70 and Hsp90 molecular chaperones. Despite this proposed key function for protein folding and maturation, it is not essential in a number of eukaryotes and bacteria lack an ortholog. We set out to identify and to characterize its eukaryote-specific function. Human cell lines and the ... [more]

Nat Commun Nov. 25, 2020; 11(1);5975 [Pubmed: 33239621]

Throughput

High Throughput

Curated By

BioGRID