ELG1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MCD1
Gene Ontology Biological Process
- DNA unwinding involved in DNA replication [IMP]
- apoptotic process [IMP]
- cellular response to DNA damage stimulus [IMP]
- double-strand break repair [IMP]
- establishment of mitotic sister chromatid cohesion [IMP]
- mitotic chromosome condensation [IMP]
- replication-born double-strand break repair via sister chromatid exchange [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
The ELG1 clamp loader plays a role in sister chromatid cohesion.
Mutations in the ELG1 gene of yeast lead to genomic instability, manifested in high levels of genetic recombination, chromosome loss, and gross chromosomal rearrangements. Elg1 shows similarity to the large subunit of the Replication Factor C clamp loader, and forms a RFC-like (RLC) complex in conjunction with the 4 small RFC subunits. Two additional RLCs exist in yeast: in one ... [more]
Throughput
- High Throughput|Low Throughput
Ontology Terms
- phenotype: resistance to chemicals (APO:0000087)
- phenotype: viability (APO:0000111)
Additional Notes
- Overexpression of SCC1 rescues the MMS sensitivity of elg1 and ctf4 mutants.
- Overexpression of SCC1 rescues the synthetic lethality of an elg1 ctf4 double mutant.
- Overexpression of SCC2 rescues the synthetic lethality of an elg1 ctf4 double mutant.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MCD1 ELG1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1931 | BioGRID | 365270 | |
| ELG1 MCD1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2727 | BioGRID | 2070429 | |
| MCD1 ELG1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1726 | BioGRID | 1963939 | |
| ELG1 MCD1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 3502456 | |
| MCD1 ELG1 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 353141 | |
| ELG1 MCD1 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 352531 | |
| ELG1 MCD1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | High | 0.0153 | BioGRID | 822344 | |
| ELG1 MCD1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 3502455 |
Curated By
- BioGRID