PRRT2
Gene Ontology Biological Process
SNAP25
Gene Ontology Biological Process
- calcium ion-dependent exocytosis of neurotransmitter [ISO]
- endosomal transport [ISO]
- long-term memory [ISO]
- long-term synaptic potentiation [IMP]
- neurotransmitter secretion [IMP]
- positive regulation of hormone secretion [ISO]
- potassium ion transmembrane transport [ISO]
- regulation of establishment of protein localization [IMP]
- regulation of ion transmembrane transport [ISO]
- regulation of neuron projection development [ISO]
- sleep [ISO]
- synaptic vesicle fusion to presynaptic membrane [IBA]
- synaptic vesicle priming [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- BLOC-1 complex [ISO]
- SNARE complex [ISO]
- actin cytoskeleton [ISO]
- axon [ISO]
- axonal growth cone [ISO]
- cell [IMP]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- endosome [ISO]
- filopodium [ISO]
- growth cone [ISO]
- intracellular organelle [ISO]
- lamellipodium [ISO]
- membrane [IDA]
- membrane raft [ISO]
- myelin sheath [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [ISO, TAS]
- synapse [IDA]
- synaptobrevin 2-SNAP-25-syntaxin-1a complex [ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [IDA, ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [ISO]
- terminal bouton [ISO]
- trans-Golgi network [IDA]
- vesicle [ISO]
- voltage-gated potassium channel complex [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.
Neuropsychiatric disorders (NPDs) are frequently co-morbid with epilepsy, but the biological basis of shared risk remains poorly understood. The 16p11.2 duplication is a copy number variant that confers risk for diverse NPDs including autism spectrum disorder, schizophrenia, intellectual disability and epilepsy. We used a mouse model of the 16p11.2 duplication (16p11.2dup/+) to uncover molecular and circuit properties associated with this ... [more]
Throughput
- Low Throughput
Additional Notes
- Immunoprecipitation of PRRT2
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PRRT2 SNAP25 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.852 | BioGRID | 2675511 |
Curated By
- BioGRID