BAIT
PRRT2
1500031I19Rik, AI195361, DSPB3
proline-rich transmembrane protein 2
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Mus musculus
PREY
ATP2B2
D6Abb2e, Gena300, PMCA2, Tmy, dfw, jog, wms, wri
ATPase, Ca++ transporting, plasma membrane 2
GO Process (31)
GO Function (9)
GO Component (12)
Gene Ontology Biological Process
- ATP catabolic process [IMP]
- auditory receptor cell stereocilium organization [IMP]
- cGMP metabolic process [IMP]
- calcium ion export [ISO]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [IMP, ISO]
- cell morphogenesis [IMP]
- cellular calcium ion homeostasis [IMP]
- cerebellar Purkinje cell differentiation [IMP]
- cerebellar Purkinje cell layer morphogenesis [IMP]
- cerebellar granule cell differentiation [IMP]
- cerebellum development [IMP]
- cochlea development [IMP]
- cytosolic calcium ion homeostasis [IMP, ISO]
- detection of mechanical stimulus involved in sensory perception of sound [IMP]
- inner ear development [IMP]
- inner ear morphogenesis [IMP]
- inner ear receptor cell differentiation [IMP]
- lactation [IMP]
- locomotion [IMP]
- locomotory behavior [IMP]
- neuromuscular process controlling balance [IMP]
- neuron differentiation [ISO]
- organelle organization [IMP]
- otolith mineralization [IMP]
- positive regulation of calcium ion transport [IMP]
- regulation of cell size [IMP]
- regulation of synaptic plasticity [IMP]
- sensory perception of sound [IGI, IMP, ISO]
- serotonin metabolic process [IMP]
- synapse organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.
Neuropsychiatric disorders (NPDs) are frequently co-morbid with epilepsy, but the biological basis of shared risk remains poorly understood. The 16p11.2 duplication is a copy number variant that confers risk for diverse NPDs including autism spectrum disorder, schizophrenia, intellectual disability and epilepsy. We used a mouse model of the 16p11.2 duplication (16p11.2dup/+) to uncover molecular and circuit properties associated with this ... [more]
Nat Commun Feb. 17, 2023; 14(1);825 [Pubmed: 36808153]
Throughput
- High Throughput
Additional Notes
- High confidence interactions included proteins that bound to anti-PRRT2 antibodies with a cut off of P<0.1 compared to an IgG control.
Curated By
- BioGRID