BAIT
PRRT2
1500031I19Rik, AI195361, DSPB3
proline-rich transmembrane protein 2
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Mus musculus
PREY
SLC1A3
AI504299, B430115D02Rik, Eaat1, GLAST, GLAST-1, GLU-T, GluT-1, Gmt1, MGluT1
solute carrier family 1 (glial high affinity glutamate transporter), member 3
GO Process (21)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- D-aspartate import [ISO]
- L-glutamate import [IMP, ISO]
- L-glutamate transmembrane transport [IMP, ISO]
- L-glutamate transport [IDA, ISO]
- auditory behavior [IMP]
- cell morphogenesis involved in neuron differentiation [IMP]
- cranial nerve development [IMP]
- gamma-aminobutyric acid biosynthetic process [IMP]
- glutamate biosynthetic process [IMP]
- glutamate metabolic process [IMP]
- malate-aspartate shuttle [ISO]
- neuromuscular process controlling balance [IMP]
- positive regulation of synaptic transmission [IMP]
- response to amino acid [ISO]
- response to antibiotic [IMP]
- response to drug [IMP]
- response to inorganic substance [ISO]
- response to light stimulus [IMP]
- response to wounding [IMP]
- sensory perception of sound [IMP]
- sodium ion transmembrane transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.
Neuropsychiatric disorders (NPDs) are frequently co-morbid with epilepsy, but the biological basis of shared risk remains poorly understood. The 16p11.2 duplication is a copy number variant that confers risk for diverse NPDs including autism spectrum disorder, schizophrenia, intellectual disability and epilepsy. We used a mouse model of the 16p11.2 duplication (16p11.2dup/+) to uncover molecular and circuit properties associated with this ... [more]
Nat Commun Feb. 17, 2023; 14(1);825 [Pubmed: 36808153]
Throughput
- High Throughput
Additional Notes
- High confidence interactions included proteins that bound to anti-PRRT2 antibodies with a cut off of P<0.1 compared to an IgG control.
Curated By
- BioGRID