BAIT
PRRT2
1500031I19Rik, AI195361, DSPB3
proline-rich transmembrane protein 2
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Mus musculus
PREY
KCNA2
Akr6a4, ENSMUSG00000074335, Gm10672, Kca1-2, Kv1.2, Mk-2
potassium voltage-gated channel, shaker-related subfamily, member 2
GO Process (8)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- neuronal action potential [ISO]
- optic nerve structural organization [IMP]
- potassium ion transmembrane transport [IBA, IDA, ISO]
- protein oligomerization [ISO]
- regulation of circadian sleep/wake cycle, non-REM sleep [IMP]
- regulation of dopamine secretion [IMP]
- regulation of ion transmembrane transport [IBA]
- sensory perception of pain [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.
Neuropsychiatric disorders (NPDs) are frequently co-morbid with epilepsy, but the biological basis of shared risk remains poorly understood. The 16p11.2 duplication is a copy number variant that confers risk for diverse NPDs including autism spectrum disorder, schizophrenia, intellectual disability and epilepsy. We used a mouse model of the 16p11.2 duplication (16p11.2dup/+) to uncover molecular and circuit properties associated with this ... [more]
Nat Commun Feb. 17, 2023; 14(1);825 [Pubmed: 36808153]
Throughput
- High Throughput
Additional Notes
- High confidence interactions included proteins that bound to anti-PRRT2 antibodies with a cut off of P<0.1 compared to an IgG control.
Curated By
- BioGRID