BAIT
PRRT2
1500031I19Rik, AI195361, DSPB3
proline-rich transmembrane protein 2
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Mus musculus
PREY
ATP1A1
Atpa-1, BC010319
ATPase, Na+/K+ transporting, alpha 1 polypeptide
GO Process (24)
GO Function (13)
GO Component (18)
Gene Ontology Biological Process
- ATP catabolic process [IMP]
- cellular potassium ion homeostasis [ISO]
- cellular response to mechanical stimulus [ISO]
- cellular response to steroid hormone stimulus [ISO]
- cellular sodium ion homeostasis [ISO]
- dephosphorylation [IMP]
- membrane hyperpolarization [ISO]
- membrane repolarization [ISO]
- negative regulation of glucocorticoid biosynthetic process [IMP]
- negative regulation of heart contraction [IMP]
- positive regulation of heart contraction [IMP]
- positive regulation of striated muscle contraction [IMP]
- potassium ion import [ISO]
- potassium ion transmembrane transport [IMP]
- potassium ion transport [ISO]
- regulation of blood pressure [IGI]
- regulation of cardiac muscle cell contraction [ISO]
- regulation of sodium ion transport [ISO]
- regulation of the force of heart contraction [IMP]
- response to drug [IMP]
- response to glycoside [IGI]
- sodium ion export from cell [ISO]
- sodium ion transmembrane transport [IMP, ISO]
- sodium ion transport [ISO]
Gene Ontology Molecular Function- ADP binding [ISO]
- ATP binding [ISO]
- ankyrin binding [ISO]
- chaperone binding [ISO]
- phosphatase activity [IMP]
- phosphatidylinositol 3-kinase binding [ISO]
- potassium ion binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase binding [ISO]
- sodium ion binding [ISO]
- sodium:potassium-exchanging ATPase activity [IDA, IMP, ISO]
- steroid hormone binding [ISO]
- ADP binding [ISO]
- ATP binding [ISO]
- ankyrin binding [ISO]
- chaperone binding [ISO]
- phosphatase activity [IMP]
- phosphatidylinositol 3-kinase binding [ISO]
- potassium ion binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase binding [ISO]
- sodium ion binding [ISO]
- sodium:potassium-exchanging ATPase activity [IDA, IMP, ISO]
- steroid hormone binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- T-tubule [IDA, ISO]
- apical plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- caveola [ISO]
- endoplasmic reticulum [ISO]
- endosome [ISO]
- extracellular vesicular exosome [ISO]
- intercalated disc [ISO]
- membrane [IDA, ISO]
- membrane raft [ISO]
- myelin sheath [IDA]
- neuronal postsynaptic density [IDA]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
- sarcolemma [IDA, ISO]
- sodium:potassium-exchanging ATPase complex [ISO]
- vesicle [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.
Neuropsychiatric disorders (NPDs) are frequently co-morbid with epilepsy, but the biological basis of shared risk remains poorly understood. The 16p11.2 duplication is a copy number variant that confers risk for diverse NPDs including autism spectrum disorder, schizophrenia, intellectual disability and epilepsy. We used a mouse model of the 16p11.2 duplication (16p11.2dup/+) to uncover molecular and circuit properties associated with this ... [more]
Nat Commun Feb. 17, 2023; 14(1);825 [Pubmed: 36808153]
Throughput
- High Throughput
Additional Notes
- High confidence interactions included proteins that bound to anti-PRRT2 antibodies with a cut off of P<0.1 compared to an IgG control.
Curated By
- BioGRID