BAIT
PRRT2
1500031I19Rik, AI195361, DSPB3
proline-rich transmembrane protein 2
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Mus musculus
PREY
PHB2
AU044498, BAP, Bap37, Bcap37, REA
prohibitin 2
GO Process (6)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
- mammary gland alveolus development [IMP]
- mammary gland branching involved in thelarche [IMP]
- negative regulation of intracellular estrogen receptor signaling pathway [IGI, IMP]
- negative regulation of mammary gland epithelial cell proliferation [IMP]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- regulation of branching involved in mammary gland duct morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.
Neuropsychiatric disorders (NPDs) are frequently co-morbid with epilepsy, but the biological basis of shared risk remains poorly understood. The 16p11.2 duplication is a copy number variant that confers risk for diverse NPDs including autism spectrum disorder, schizophrenia, intellectual disability and epilepsy. We used a mouse model of the 16p11.2 duplication (16p11.2dup/+) to uncover molecular and circuit properties associated with this ... [more]
Nat Commun Feb. 17, 2023; 14(1);825 [Pubmed: 36808153]
Throughput
- High Throughput
Additional Notes
- High confidence interactions included proteins that bound to anti-PRRT2 antibodies with a cut off of P<0.1 compared to an IgG control.
Curated By
- BioGRID