BAIT
PRRT2
1500031I19Rik, AI195361, DSPB3
proline-rich transmembrane protein 2
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Mus musculus
PREY
RAB5A
2410015H04Rik, AI663973, AU021172, nnyRab5a
RAB5A, member RAS oncogene family
GO Process (16)
GO Function (6)
GO Component (26)
Gene Ontology Biological Process
- GTP catabolic process [IDA, ISO]
- Rab protein signal transduction [IBA]
- early endosome to late endosome transport [ISO]
- endocytosis [IDA, ISO]
- endosome organization [ISO]
- intracellular protein transport [IBA]
- positive regulation of exocytosis [ISO]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- receptor internalization involved in canonical Wnt signaling pathway [ISO]
- regulation of endocytosis [IBA]
- regulation of endosome size [ISO]
- regulation of filopodium assembly [IBA, ISO]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of synaptic vesicle exocytosis [ISO]
- synaptic vesicle recycling [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- axon [ISO]
- axon terminus [ISO]
- cell [IBA]
- cytoplasm [IDA, ISO]
- cytoplasmic side of early endosome membrane [ISO]
- cytosol [ISO]
- dendrite [ISO]
- early endosome [IDA, ISO]
- endocytic vesicle [IDA]
- endosome [IDA, ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IBA]
- membrane raft [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- perinuclear region of cytoplasm [ISO]
- phagocytic vesicle [IDA]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
- recycling endosome [ISO]
- ruffle [IDA]
- somatodendritic compartment [ISO]
- synaptic vesicle [ISO]
- terminal bouton [ISO]
- zymogen granule membrane [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.
Neuropsychiatric disorders (NPDs) are frequently co-morbid with epilepsy, but the biological basis of shared risk remains poorly understood. The 16p11.2 duplication is a copy number variant that confers risk for diverse NPDs including autism spectrum disorder, schizophrenia, intellectual disability and epilepsy. We used a mouse model of the 16p11.2 duplication (16p11.2dup/+) to uncover molecular and circuit properties associated with this ... [more]
Nat Commun Feb. 17, 2023; 14(1);825 [Pubmed: 36808153]
Throughput
- High Throughput
Additional Notes
- High confidence interactions included proteins that bound to anti-PRRT2 antibodies with a cut off of P<0.1 compared to an IgG control.
Curated By
- BioGRID