BAIT
PRRT2
1500031I19Rik, AI195361, DSPB3
proline-rich transmembrane protein 2
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Mus musculus
PREY
GRM7
6330570A01Rik, BB176677, C030018L03, E130018M02Rik, Gpr1g, Gprc1g, mGluR7
glutamate receptor, metabotropic 7
GO Process (20)
GO Function (13)
GO Component (21)
Gene Ontology Biological Process
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway [IBA, ISO, TAS]
- adult behavior [IMP]
- associative learning [IMP]
- behavioral fear response [IMP]
- calcium ion transmembrane transport [IDA]
- conditioned taste aversion [IMP]
- memory [IMP]
- multicellular organismal response to stress [IMP]
- negative regulation of adenylate cyclase activity [ISO]
- negative regulation of cAMP biosynthetic process [ISO]
- negative regulation of glutamate secretion [ISO]
- neurological system process [IMP]
- regulation of cyclase activity [ISO]
- regulation of ion transmembrane transport [IDA]
- regulation of neuron death [TAS]
- regulation of synaptic transmission, glutamatergic [IBA]
- sensory perception of sound [ISO]
- short-term memory [IMP]
- synaptic transmission [IDA, ISO]
- transmission of nerve impulse [IMP]
Gene Ontology Molecular Function- PDZ domain binding [ISO, TAS]
- adenylate cyclase inhibiting G-protein coupled glutamate receptor activity [ISO]
- adenylate cyclase inhibitor activity [ISO]
- calcium channel regulator activity [IDA]
- calcium ion binding [ISO]
- calcium-dependent protein binding [ISO]
- calmodulin binding [ISO]
- glutamate binding [ISO]
- glutamate receptor activity [ISO]
- group III metabotropic glutamate receptor activity [IBA, ISO, TAS]
- protein homodimerization activity [ISO]
- serine binding [ISO]
- voltage-gated calcium channel activity [IDA]
- PDZ domain binding [ISO, TAS]
- adenylate cyclase inhibiting G-protein coupled glutamate receptor activity [ISO]
- adenylate cyclase inhibitor activity [ISO]
- calcium channel regulator activity [IDA]
- calcium ion binding [ISO]
- calcium-dependent protein binding [ISO]
- calmodulin binding [ISO]
- glutamate binding [ISO]
- glutamate receptor activity [ISO]
- group III metabotropic glutamate receptor activity [IBA, ISO, TAS]
- protein homodimerization activity [ISO]
- serine binding [ISO]
- voltage-gated calcium channel activity [IDA]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- asymmetric synapse [ISO]
- axon [ISO]
- axon terminus [ISO]
- cell cortex [ISO]
- cell surface [ISO]
- dendrite [ISO]
- dendritic shaft [ISO]
- integral component of membrane [ISO]
- integral component of plasma membrane [IBA]
- membrane [ISO]
- neuronal cell body [ISO]
- postsynaptic membrane [ISO]
- presynaptic active zone [ISO]
- presynaptic active zone membrane [TAS]
- presynaptic membrane [IDA, ISO]
- protein complex [ISO]
- receptor complex [ISO]
- rough endoplasmic reticulum [ISO]
- synapse [ISO]
- terminal bouton [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.
Neuropsychiatric disorders (NPDs) are frequently co-morbid with epilepsy, but the biological basis of shared risk remains poorly understood. The 16p11.2 duplication is a copy number variant that confers risk for diverse NPDs including autism spectrum disorder, schizophrenia, intellectual disability and epilepsy. We used a mouse model of the 16p11.2 duplication (16p11.2dup/+) to uncover molecular and circuit properties associated with this ... [more]
Nat Commun Feb. 17, 2023; 14(1);825 [Pubmed: 36808153]
Throughput
- High Throughput
Additional Notes
- High confidence interactions included proteins that bound to anti-PRRT2 antibodies with a cut off of P<0.1 compared to an IgG control.
Curated By
- BioGRID