BAIT
PRRT2
1500031I19Rik, AI195361, DSPB3
proline-rich transmembrane protein 2
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Mus musculus
PREY
RAB8B
5930437D16, D330025I23Rik
RAB8B, member RAS oncogene family
GO Process (15)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- GTP catabolic process [IBA]
- Golgi vesicle fusion to target membrane [IBA]
- Rab protein signal transduction [IBA]
- adherens junction organization [ISO]
- antigen processing and presentation [ISO]
- cellular response to insulin stimulus [IBA]
- intracellular protein transport [IBA]
- positive regulation of cell projection organization [ISO]
- positive regulation of corticotropin secretion [ISO]
- protein import into peroxisome membrane [ISO]
- protein localization to plasma membrane [IBA]
- protein secretion [IBA]
- regulation of exocytosis [IBA]
- synaptic vesicle exocytosis [IBA]
- vesicle docking involved in exocytosis [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell tip [ISO]
- cytoplasmic vesicle [ISO]
- endosome [IBA]
- extracellular vesicular exosome [ISO]
- mitochondrion [IDA]
- perinuclear region of cytoplasm [ISO]
- peroxisomal membrane [ISO]
- phagocytic vesicle [ISO]
- plasma membrane [IBA, ISO]
- secretory granule membrane [IBA]
- synaptic vesicle [IBA]
- trans-Golgi network transport vesicle [IBA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.
Neuropsychiatric disorders (NPDs) are frequently co-morbid with epilepsy, but the biological basis of shared risk remains poorly understood. The 16p11.2 duplication is a copy number variant that confers risk for diverse NPDs including autism spectrum disorder, schizophrenia, intellectual disability and epilepsy. We used a mouse model of the 16p11.2 duplication (16p11.2dup/+) to uncover molecular and circuit properties associated with this ... [more]
Nat Commun Feb. 17, 2023; 14(1);825 [Pubmed: 36808153]
Throughput
- High Throughput
Additional Notes
- High confidence interactions included proteins that bound to anti-PRRT2 antibodies with a cut off of P<0.1 compared to an IgG control.
Curated By
- BioGRID