BAIT
PRRT2
1500031I19Rik, AI195361, DSPB3
proline-rich transmembrane protein 2
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Mus musculus
PREY
VAMP7
Sybl1, TI-VAMP, VAMP-7
vesicle-associated membrane protein 7
GO Process (19)
GO Function (3)
GO Component (24)
Gene Ontology Biological Process
- ER to Golgi vesicle-mediated transport [ISO, ISS]
- Golgi to plasma membrane protein transport [IMP]
- SNARE complex assembly [IDA]
- calcium ion-dependent exocytosis [ISO, ISS]
- endocytosis [IBA]
- endosome to lysosome transport [IBA, ISO, ISS]
- eosinophil degranulation [ISO, ISS]
- exocytosis [IBA, ISO]
- natural killer cell degranulation [ISO]
- neutrophil degranulation [ISO, ISS]
- phagocytosis, engulfment [ISO, ISS]
- positive regulation of dendrite morphogenesis [IMP]
- positive regulation of histamine secretion by mast cell [ISO]
- regulation of protein targeting to vacuolar membrane [IMP]
- triglyceride transport [ISO]
- vesicle fusion [IBA, ISO, ISS]
- vesicle fusion with Golgi apparatus [ISO]
- vesicle transport along microtubule [ISO]
- vesicle-mediated transport [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- SNARE complex [IBA, ISO, ISS]
- apical part of cell [IDA]
- azurophil granule membrane [ISO]
- cell [IMP]
- cell surface [IDA]
- cytoplasm [ISO]
- endoplasmic reticulum membrane [ISO, ISS]
- extracellular vesicular exosome [ISO]
- intracellular [IMP]
- intracellular membrane-bounded organelle [ISO]
- lamellipodium [IDA, ISO]
- late endosome membrane [ISO, ISS]
- lysosomal membrane [ISO, ISS]
- membrane [ISO]
- neuron projection [IDA, ISO]
- perinuclear region of cytoplasm [IDA]
- phagocytic vesicle [IDA]
- plasma membrane [ISO]
- platelet alpha granule [ISO]
- pseudopodium [IDA, ISO]
- secretory granule [ISO]
- secretory granule membrane [ISO]
- trans-Golgi network [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.
Neuropsychiatric disorders (NPDs) are frequently co-morbid with epilepsy, but the biological basis of shared risk remains poorly understood. The 16p11.2 duplication is a copy number variant that confers risk for diverse NPDs including autism spectrum disorder, schizophrenia, intellectual disability and epilepsy. We used a mouse model of the 16p11.2 duplication (16p11.2dup/+) to uncover molecular and circuit properties associated with this ... [more]
Nat Commun Feb. 17, 2023; 14(1);825 [Pubmed: 36808153]
Throughput
- High Throughput
Additional Notes
- High confidence interactions included proteins that bound to anti-PRRT2 antibodies with a cut off of P<0.1 compared to an IgG control.
Curated By
- BioGRID