BAIT
PRRT2
1500031I19Rik, AI195361, DSPB3
proline-rich transmembrane protein 2
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Mus musculus
PREY
WFS1
AI481085, wolframin
Wolfram syndrome 1 homolog (human)
GO Process (24)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [IDA]
- calcium ion homeostasis [ISO]
- endoplasmic reticulum calcium ion homeostasis [ISO]
- endoplasmic reticulum unfolded protein response [IDA, IMP]
- glucose homeostasis [ISO]
- kidney development [ISO]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IMP]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of programmed cell death [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of type B pancreatic cell apoptotic process [IMP, ISO]
- neurological system process [ISO]
- polyubiquitinated misfolded protein transport [IDA]
- positive regulation of calcium ion transport [ISO]
- positive regulation of growth [IMP]
- positive regulation of protein metabolic process [ISO]
- positive regulation of protein ubiquitination [IDA]
- positive regulation of proteolysis [IDA]
- protein stabilization [IMP]
- regulation of cell cycle [NAS]
- renal water homeostasis [ISO]
- response to endoplasmic reticulum stress [IDA, ISO]
- sensory perception of sound [ISO]
- visual perception [ISO, NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.
Neuropsychiatric disorders (NPDs) are frequently co-morbid with epilepsy, but the biological basis of shared risk remains poorly understood. The 16p11.2 duplication is a copy number variant that confers risk for diverse NPDs including autism spectrum disorder, schizophrenia, intellectual disability and epilepsy. We used a mouse model of the 16p11.2 duplication (16p11.2dup/+) to uncover molecular and circuit properties associated with this ... [more]
Nat Commun Feb. 17, 2023; 14(1);825 [Pubmed: 36808153]
Throughput
- High Throughput
Additional Notes
- High confidence interactions included proteins that bound to anti-PRRT2 antibodies with a cut off of P<0.1 compared to an IgG control.
Curated By
- BioGRID