BAIT
PRRT2
1500031I19Rik, AI195361, DSPB3
proline-rich transmembrane protein 2
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Mus musculus
PREY
PPAP2B
1110003O22Rik, 2610002D05Rik, AV025606, D4Bwg0538e, D4Bwg1535e, Lpp3, Ppab2b, RP23-104G20.1
phosphatidic acid phosphatase type 2B
GO Process (18)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- Bergmann glial cell differentiation [IMP]
- blood vessel development [IMP]
- canonical Wnt signaling pathway [IDA]
- canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion [ISO]
- canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration [ISO]
- canonical Wnt signaling pathway involved in positive regulation of wound healing [ISO]
- cell adhesion [IDA]
- dephosphorylation [IMP]
- gastrulation with mouth forming second [IMP]
- homotypic cell-cell adhesion [ISO]
- negative regulation of protein phosphorylation [IDA, ISO]
- phospholipid metabolic process [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA, ISO]
- protein stabilization [IDA, ISO]
- regulation of Wnt signaling pathway [IDA]
- regulation of sphingolipid mediated signaling pathway [IMP]
- single organismal cell-cell adhesion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.
Neuropsychiatric disorders (NPDs) are frequently co-morbid with epilepsy, but the biological basis of shared risk remains poorly understood. The 16p11.2 duplication is a copy number variant that confers risk for diverse NPDs including autism spectrum disorder, schizophrenia, intellectual disability and epilepsy. We used a mouse model of the 16p11.2 duplication (16p11.2dup/+) to uncover molecular and circuit properties associated with this ... [more]
Nat Commun Feb. 17, 2023; 14(1);825 [Pubmed: 36808153]
Throughput
- High Throughput
Additional Notes
- High confidence interactions included proteins that bound to anti-PRRT2 antibodies with a cut off of P<0.1 compared to an IgG control.
Curated By
- BioGRID