BAIT
PRRT2
1500031I19Rik, AI195361, DSPB3
proline-rich transmembrane protein 2
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Mus musculus
PREY
CXADR
2610206D03Rik, AU016810, AW553441, CAR, MCAR, MCVADR
coxsackie virus and adenovirus receptor
GO Process (16)
GO Function (8)
GO Component (18)
Gene Ontology Biological Process
- AV node cell to bundle of His cell communication [IMP]
- actin cytoskeleton reorganization [ISO]
- cardiac muscle fiber development [IMP]
- cell-cell junction organization [IMP]
- defense response to virus [ISO]
- epithelial structure maintenance [ISO]
- gamma-delta T cell activation [IDA]
- heart development [IMP]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISO]
- homotypic cell-cell adhesion [ISO]
- mitochondrion organization [IMP]
- negative regulation of cardiac muscle cell proliferation [IMP]
- neutrophil chemotaxis [ISO]
- positive regulation of epithelial cell proliferation involved in wound healing [IC]
- single organismal cell-cell adhesion [IMP]
- transepithelial transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- acrosomal vesicle [IDA]
- adherens junction [ISO]
- apicolateral plasma membrane [ISO]
- basolateral plasma membrane [IDA, ISO]
- cell body [IDA]
- cell junction [ISO]
- cell-cell junction [IDA, ISO]
- extracellular space [ISO]
- filopodium [IDA]
- growth cone [IDA]
- intercalated disc [IDA, ISO]
- membrane raft [ISO]
- neuromuscular junction [ISO]
- neuron projection [IDA, ISO]
- nucleoplasm [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- tight junction [IDA, ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.
Neuropsychiatric disorders (NPDs) are frequently co-morbid with epilepsy, but the biological basis of shared risk remains poorly understood. The 16p11.2 duplication is a copy number variant that confers risk for diverse NPDs including autism spectrum disorder, schizophrenia, intellectual disability and epilepsy. We used a mouse model of the 16p11.2 duplication (16p11.2dup/+) to uncover molecular and circuit properties associated with this ... [more]
Nat Commun Feb. 17, 2023; 14(1);825 [Pubmed: 36808153]
Throughput
- High Throughput
Additional Notes
- High confidence interactions included proteins that bound to anti-PRRT2 antibodies with a cut off of P<0.1 compared to an IgG control.
Curated By
- BioGRID