BAIT
USP48
2810449C13Rik, AI115503, BC021769, D330022K21Rik, Usp31, RP23-277N22.2
ubiquitin specific peptidase 48
GO Process (3)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ANXA1
Anx-1, Anx-A1, C430014K04Rik, Lpc-1, Lpc1
annexin A1
GO Process (25)
GO Function (13)
GO Component (14)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- DNA duplex unwinding [ISO]
- DNA rewinding [ISO]
- DNA strand renaturation [ISO]
- alpha-beta T cell differentiation [IMP]
- arachidonic acid secretion [IMP]
- cell surface receptor signaling pathway [ISO]
- cellular response to glucocorticoid stimulus [ISO]
- cellular response to hydrogen peroxide [ISO]
- insulin secretion [ISO]
- keratinocyte differentiation [ISO]
- negative regulation of interleukin-8 secretion [ISO]
- negative regulation of phospholipase A2 activity [ISO]
- negative regulation of protein secretion [ISO]
- neutrophil clearance [ISO]
- neutrophil homeostasis [IMP, ISO]
- peptide cross-linking [ISO]
- positive regulation of G1/S transition of mitotic cell cycle [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of neutrophil apoptotic process [IMP]
- positive regulation of prostaglandin biosynthetic process [ISO]
- positive regulation of vesicle fusion [ISO]
- prolactin secretion [ISO]
- regulation of cell proliferation [IMP]
- signal transduction [IMP]
Gene Ontology Molecular Function- annealing helicase activity [ISO]
- calcium-dependent phospholipid binding [ISO]
- calcium-dependent protein binding [ISO]
- double-stranded DNA-dependent ATPase activity [ISO]
- helicase activity [ISO]
- phospholipase A2 inhibitor activity [ISO]
- phospholipid binding [ISO]
- protein binding [IPI]
- protein binding, bridging [ISO]
- protein homodimerization activity [ISO]
- single-stranded DNA binding [ISO]
- single-stranded RNA binding [ISO]
- structural molecule activity [ISO]
- annealing helicase activity [ISO]
- calcium-dependent phospholipid binding [ISO]
- calcium-dependent protein binding [ISO]
- double-stranded DNA-dependent ATPase activity [ISO]
- helicase activity [ISO]
- phospholipase A2 inhibitor activity [ISO]
- phospholipid binding [ISO]
- protein binding [IPI]
- protein binding, bridging [ISO]
- protein homodimerization activity [ISO]
- single-stranded DNA binding [ISO]
- single-stranded RNA binding [ISO]
- structural molecule activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.
Proteins related to the ubiquitin-proteasome system play an important role during the differentiation and ciliogenesis of photoreceptor cells. Mutations in several genes involved in ubiquitination and proteostasis have been identified as causative of inherited retinal dystrophies (IRDs) and ciliopathies. USP48 is a deubiquitinating enzyme whose role in the retina is still unexplored although previous studies indicate its relevance for neurosensory ... [more]
Int J Mol Sci Oct. 19, 2022; 23(20); [Pubmed: 36293380]
Throughput
- High Throughput
Curated By
- BioGRID