BAIT
USP48
2810449C13Rik, AI115503, BC021769, D330022K21Rik, Usp31, RP23-277N22.2
ubiquitin specific peptidase 48
GO Process (3)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CALR
CRT, Calregulin
calreticulin
GO Process (22)
GO Function (13)
GO Component (21)
Gene Ontology Biological Process
- cell cycle arrest [ISO]
- cellular senescence [IMP, ISO]
- chaperone-mediated protein folding [ISO]
- cortical actin cytoskeleton organization [IDA]
- negative regulation of intracellular steroid hormone receptor signaling pathway [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of retinoic acid receptor signaling pathway [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of translation [ISO]
- peptide antigen assembly with MHC class I protein complex [IMP]
- positive regulation of DNA replication [ISO]
- positive regulation of cell cycle [IMP, ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of dendritic cell chemotaxis [ISO]
- positive regulation of gene expression [IMP]
- positive regulation of phagocytosis [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- protein export from nucleus [ISO]
- protein localization to nucleus [IMP, ISO]
- protein stabilization [IDA]
- regulation of meiosis [IDA]
Gene Ontology Molecular Function- androgen receptor binding [ISO]
- calcium ion binding [IDA, ISO]
- carbohydrate binding [IDA]
- glycoprotein binding [ISO]
- hormone binding [ISO]
- integrin binding [ISO]
- iron ion binding [ISO]
- mRNA binding [IDA, ISO]
- peptide binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [ISO]
- androgen receptor binding [ISO]
- calcium ion binding [IDA, ISO]
- carbohydrate binding [IDA]
- glycoprotein binding [ISO]
- hormone binding [ISO]
- integrin binding [ISO]
- iron ion binding [ISO]
- mRNA binding [IDA, ISO]
- peptide binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- MHC class I peptide loading complex [IMP]
- acrosomal vesicle [ISO]
- cell surface [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- endoplasmic reticulum [IDA, ISO, ISS]
- endoplasmic reticulum lumen [IDA, ISO]
- external side of plasma membrane [IDA]
- extracellular matrix [ISO]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- polysome [IDA]
- protein complex [ISO]
- sarcoplasmic reticulum [ISO]
- smooth endoplasmic reticulum [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.
Proteins related to the ubiquitin-proteasome system play an important role during the differentiation and ciliogenesis of photoreceptor cells. Mutations in several genes involved in ubiquitination and proteostasis have been identified as causative of inherited retinal dystrophies (IRDs) and ciliopathies. USP48 is a deubiquitinating enzyme whose role in the retina is still unexplored although previous studies indicate its relevance for neurosensory ... [more]
Int J Mol Sci Oct. 19, 2022; 23(20); [Pubmed: 36293380]
Throughput
- High Throughput
Curated By
- BioGRID