BAIT
USP48
2810449C13Rik, AI115503, BC021769, D330022K21Rik, Usp31, RP23-277N22.2
ubiquitin specific peptidase 48
GO Process (3)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
GNAI2
C76432, Galphai2, Gia, Gnai-2
guanine nucleotide binding protein (G protein), alpha inhibiting 2
GO Process (14)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [IMP]
- G-protein coupled receptor signaling pathway [ISO]
- GTP catabolic process [IBA]
- activation of MAPKK activity [ISO]
- adenosine receptor signaling pathway [IBA, ISO]
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [IMP, ISA]
- cell division [ISO]
- cell proliferation [IPI]
- gamma-aminobutyric acid signaling pathway [IBA, ISO]
- intracellular signal transduction [ISO]
- negative regulation of synaptic transmission [ISO]
- positive regulation of cell proliferation [ISO]
- regulation of calcium ion transport [ISO]
- regulation of heart contraction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.
Proteins related to the ubiquitin-proteasome system play an important role during the differentiation and ciliogenesis of photoreceptor cells. Mutations in several genes involved in ubiquitination and proteostasis have been identified as causative of inherited retinal dystrophies (IRDs) and ciliopathies. USP48 is a deubiquitinating enzyme whose role in the retina is still unexplored although previous studies indicate its relevance for neurosensory ... [more]
Int J Mol Sci Oct. 19, 2022; 23(20); [Pubmed: 36293380]
Throughput
- High Throughput
Curated By
- BioGRID