BAIT
USP48
2810449C13Rik, AI115503, BC021769, D330022K21Rik, Usp31, RP23-277N22.2
ubiquitin specific peptidase 48
GO Process (3)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
THY1
CD90, T25, Thy-1, Thy-1.2, Thy1.1, Thy1.2
thymus cell antigen 1, theta
GO Process (14)
GO Function (5)
GO Component (14)
Gene Ontology Biological Process
- T cell receptor signaling pathway [ISO]
- angiogenesis [IDA]
- cytoskeleton organization [ISO]
- focal adhesion assembly [ISO]
- negative regulation of T cell receptor signaling pathway [IDA]
- negative regulation of axonogenesis [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of protein kinase activity [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of Rho GTPase activity [ISO]
- positive regulation of T cell activation [ISO]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- retinal cone cell development [IMP]
- single organismal cell-cell adhesion [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- anchored component of external side of plasma membrane [IDA]
- anchored component of plasma membrane [ISO]
- apical plasma membrane [ISO]
- cell surface [ISO]
- cytosol [ISO]
- dendrite [IDA]
- endoplasmic reticulum [ISO]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- growth cone [ISO]
- membrane raft [IDA]
- myelin sheath [IDA]
- plasma membrane [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.
Proteins related to the ubiquitin-proteasome system play an important role during the differentiation and ciliogenesis of photoreceptor cells. Mutations in several genes involved in ubiquitination and proteostasis have been identified as causative of inherited retinal dystrophies (IRDs) and ciliopathies. USP48 is a deubiquitinating enzyme whose role in the retina is still unexplored although previous studies indicate its relevance for neurosensory ... [more]
Int J Mol Sci Oct. 19, 2022; 23(20); [Pubmed: 36293380]
Throughput
- High Throughput
Curated By
- BioGRID