BAIT
USP48
2810449C13Rik, AI115503, BC021769, D330022K21Rik, Usp31, RP23-277N22.2
ubiquitin specific peptidase 48
GO Process (3)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
FIS1
2010003O14Rik, Ttc11
fission 1 (mitochondrial outer membrane) homolog (yeast)
GO Process (18)
GO Function (1)
GO Component (8)
Gene Ontology Biological Process
- calcium-mediated signaling using intracellular calcium source [ISO]
- mitochondrial fission [IMP, ISO]
- mitochondrial fragmentation involved in apoptotic process [ISO]
- mitochondrial fusion [ISO]
- mitochondrion degradation [ISO]
- mitochondrion morphogenesis [ISO]
- negative regulation of endoplasmic reticulum calcium ion concentration [ISO]
- peroxisome fission [ISO, ISS]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of mitochondrial calcium ion concentration [ISO]
- positive regulation of mitochondrial fission [ISO]
- positive regulation of protein targeting to membrane [ISO]
- protein homooligomerization [ISO]
- protein targeting to mitochondrion [ISO]
- regulation of mitochondrion organization [ISO]
- release of cytochrome c from mitochondria [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.
Proteins related to the ubiquitin-proteasome system play an important role during the differentiation and ciliogenesis of photoreceptor cells. Mutations in several genes involved in ubiquitination and proteostasis have been identified as causative of inherited retinal dystrophies (IRDs) and ciliopathies. USP48 is a deubiquitinating enzyme whose role in the retina is still unexplored although previous studies indicate its relevance for neurosensory ... [more]
Int J Mol Sci Oct. 19, 2022; 23(20); [Pubmed: 36293380]
Throughput
- High Throughput
Curated By
- BioGRID