BAIT
USP48
2810449C13Rik, AI115503, BC021769, D330022K21Rik, Usp31, RP23-277N22.2
ubiquitin specific peptidase 48
GO Process (3)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NME1
AL024257, NDPK-A, NM23-M1, NM23A, RP23-378I13.1
NME/NM23 nucleoside diphosphate kinase 1
GO Process (14)
GO Function (14)
GO Component (10)
Gene Ontology Biological Process
- DNA catabolic process [ISO]
- lactation [IMP]
- mammary gland development [IMP]
- negative regulation of gene expression [ISO]
- negative regulation of myeloid leukocyte differentiation [ISO]
- nucleic acid phosphodiester bond hydrolysis [ISO]
- nucleoside diphosphate phosphorylation [IBA, ISO]
- nucleoside triphosphate biosynthetic process [IBA]
- positive regulation of DNA binding [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of neuron projection development [ISO]
- purine nucleotide metabolic process [IBA]
- pyrimidine nucleotide metabolic process [IBA]
- regulation of apoptotic process [IBA]
Gene Ontology Molecular Function- ATP binding [ISO]
- GTP binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- deoxyribonuclease activity [ISO]
- enzyme binding [ISO]
- gamma-tubulin binding [ISO]
- identical protein binding [ISO]
- intermediate filament binding [ISO]
- magnesium ion binding [ISO]
- nucleoside diphosphate kinase activity [IBA, ISO]
- poly(A) RNA binding [ISO]
- protein kinase binding [ISO]
- ribosomal small subunit binding [ISO]
- single-stranded DNA binding [ISO]
- ATP binding [ISO]
- GTP binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- deoxyribonuclease activity [ISO]
- enzyme binding [ISO]
- gamma-tubulin binding [ISO]
- identical protein binding [ISO]
- intermediate filament binding [ISO]
- magnesium ion binding [ISO]
- nucleoside diphosphate kinase activity [IBA, ISO]
- poly(A) RNA binding [ISO]
- protein kinase binding [ISO]
- ribosomal small subunit binding [ISO]
- single-stranded DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.
Proteins related to the ubiquitin-proteasome system play an important role during the differentiation and ciliogenesis of photoreceptor cells. Mutations in several genes involved in ubiquitination and proteostasis have been identified as causative of inherited retinal dystrophies (IRDs) and ciliopathies. USP48 is a deubiquitinating enzyme whose role in the retina is still unexplored although previous studies indicate its relevance for neurosensory ... [more]
Int J Mol Sci Oct. 19, 2022; 23(20); [Pubmed: 36293380]
Throughput
- High Throughput
Curated By
- BioGRID