BAIT
USP48
2810449C13Rik, AI115503, BC021769, D330022K21Rik, Usp31, RP23-277N22.2
ubiquitin specific peptidase 48
GO Process (3)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DDX3X
D1Pas1-rs2, Ddx3, Fin14, RP23-158L19.4
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked
GO Process (27)
GO Function (14)
GO Component (6)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- DNA duplex unwinding [ISO]
- RNA secondary structure unwinding [ISO]
- cellular response to arsenic-containing substance [ISO]
- cellular response to osmotic stress [ISO]
- chromosome segregation [ISO]
- extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- innate immune response [ISO]
- intracellular signal transduction [ISO]
- intrinsic apoptotic signaling pathway [ISO]
- mature ribosome assembly [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of intrinsic apoptotic signaling pathway [ISO]
- negative regulation of protein complex assembly [ISO]
- negative regulation of translation [ISO]
- positive regulation of G1/S transition of mitotic cell cycle [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of translation [ISO]
- positive regulation of translational initiation [ISO]
- positive regulation of viral genome replication [ISO]
- response to virus [ISO]
- stress granule assembly [ISO]
Gene Ontology Molecular Function- ATP-dependent DNA helicase activity [ISO]
- ATP-dependent RNA helicase activity [ISO]
- ATPase activity [ISO]
- DNA binding [ISO]
- RNA binding [ISO]
- RNA stem-loop binding [ISO]
- eukaryotic initiation factor 4E binding [ISO]
- mRNA 5'-UTR binding [ISO]
- poly(A) RNA binding [ISO]
- poly(A) binding [ISO]
- protein binding [IPI]
- ribosomal small subunit binding [ISO]
- transcription factor binding [ISO]
- translation initiation factor binding [ISO]
- ATP-dependent DNA helicase activity [ISO]
- ATP-dependent RNA helicase activity [ISO]
- ATPase activity [ISO]
- DNA binding [ISO]
- RNA binding [ISO]
- RNA stem-loop binding [ISO]
- eukaryotic initiation factor 4E binding [ISO]
- mRNA 5'-UTR binding [ISO]
- poly(A) RNA binding [ISO]
- poly(A) binding [ISO]
- protein binding [IPI]
- ribosomal small subunit binding [ISO]
- transcription factor binding [ISO]
- translation initiation factor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.
Proteins related to the ubiquitin-proteasome system play an important role during the differentiation and ciliogenesis of photoreceptor cells. Mutations in several genes involved in ubiquitination and proteostasis have been identified as causative of inherited retinal dystrophies (IRDs) and ciliopathies. USP48 is a deubiquitinating enzyme whose role in the retina is still unexplored although previous studies indicate its relevance for neurosensory ... [more]
Int J Mol Sci Oct. 19, 2022; 23(20); [Pubmed: 36293380]
Throughput
- High Throughput
Curated By
- BioGRID