BAIT
USP48
2810449C13Rik, AI115503, BC021769, D330022K21Rik, Usp31, RP23-277N22.2
ubiquitin specific peptidase 48
GO Process (3)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HSP90AA1
86kDa, 89kDa, AL024080, AL024147, Hsp86-1, Hsp89, Hsp90, Hspca, hsp4, RP23-60K23.1
heat shock protein 90, alpha (cytosolic), class A member 1
GO Process (13)
GO Function (20)
GO Component (18)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- chaperone-mediated protein complex assembly [ISO]
- neuron migration [ISO]
- nitric oxide biosynthetic process [TAS]
- positive regulation of cell size [ISO]
- positive regulation of cytotoxic T cell differentiation [TAS]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of nitric oxide biosynthetic process [IDA]
- positive regulation of protein import into nucleus, translocation [ISO]
- protein import into mitochondrial outer membrane [ISO]
- protein refolding [TAS]
- regulation of catalytic activity [ISO]
- response to unfolded protein [TAS]
Gene Ontology Molecular Function- ATP binding [ISO]
- ATPase activity [ISO]
- CTP binding [ISO]
- GTP binding [ISO]
- MHC class II protein complex binding [ISO]
- Rho GDP-dissociation inhibitor binding [ISO]
- TPR domain binding [ISO]
- UTP binding [ISO]
- dATP binding [ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- mRNA binding [ISO]
- nitric-oxide synthase regulator activity [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- sulfonylurea receptor binding [ISO]
- unfolded protein binding [TAS]
- ATP binding [ISO]
- ATPase activity [ISO]
- CTP binding [ISO]
- GTP binding [ISO]
- MHC class II protein complex binding [ISO]
- Rho GDP-dissociation inhibitor binding [ISO]
- TPR domain binding [ISO]
- UTP binding [ISO]
- dATP binding [ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- mRNA binding [ISO]
- nitric-oxide synthase regulator activity [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- sulfonylurea receptor binding [ISO]
- unfolded protein binding [TAS]
Gene Ontology Cellular Component
- apical plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- brush border membrane [ISO]
- cell surface [ISO]
- cytoplasm [IDA, ISO]
- cytosol [IDA, ISO, TAS]
- extracellular matrix [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IDA]
- membrane [ISO]
- mitochondrion [ISO]
- myelin sheath [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- protein complex [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.
Proteins related to the ubiquitin-proteasome system play an important role during the differentiation and ciliogenesis of photoreceptor cells. Mutations in several genes involved in ubiquitination and proteostasis have been identified as causative of inherited retinal dystrophies (IRDs) and ciliopathies. USP48 is a deubiquitinating enzyme whose role in the retina is still unexplored although previous studies indicate its relevance for neurosensory ... [more]
Int J Mol Sci Oct. 19, 2022; 23(20); [Pubmed: 36293380]
Throughput
- High Throughput
Curated By
- BioGRID