BAIT
USP48
2810449C13Rik, AI115503, BC021769, D330022K21Rik, Usp31, RP23-277N22.2
ubiquitin specific peptidase 48
GO Process (3)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CRYAB
Crya-2, Crya2, HspB5, P23
crystallin, alpha B
GO Process (19)
GO Function (7)
GO Component (14)
Gene Ontology Biological Process
- apoptotic process involved in morphogenesis [IGI]
- camera-type eye development [IGI]
- cellular response to gamma radiation [ISO]
- lens development in camera-type eye [IGI]
- microtubule polymerization or depolymerization [ISO]
- muscle organ development [IGI]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IGI]
- negative regulation of gene expression [IMP]
- negative regulation of intracellular transport [ISO]
- negative regulation of reactive oxygen species metabolic process [ISO]
- protein folding [ISO]
- protein homooligomerization [ISO]
- regulation of cell death [ISO]
- response to hydrogen peroxide [IMP]
- response to hypoxia [IMP]
- stress-activated MAPK cascade [ISO]
- tubulin complex assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.
Proteins related to the ubiquitin-proteasome system play an important role during the differentiation and ciliogenesis of photoreceptor cells. Mutations in several genes involved in ubiquitination and proteostasis have been identified as causative of inherited retinal dystrophies (IRDs) and ciliopathies. USP48 is a deubiquitinating enzyme whose role in the retina is still unexplored although previous studies indicate its relevance for neurosensory ... [more]
Int J Mol Sci Oct. 19, 2022; 23(20); [Pubmed: 36293380]
Throughput
- High Throughput
Curated By
- BioGRID