BAIT

MAP1LC3A

ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3, RP11-346K17.1
microtubule-associated protein 1 light chain 3 alpha
Autophagy Project
Homo sapiens
PREY

NLRP6

AVR, CLR11.4, NALP6, NAVR, NAVR/AVR, PAN3, PYPAF5
NLR family, pyrin domain containing 6
GO Process (2)
GO Function (1)
GO Component (0)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Homo sapiens

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

Estrogen receptor ? activation inhibits colitis by promoting NLRP6-mediated autophagy.

Fan W, Ding C, Liu S, Gao X, Shen X, De Boevre M, Gao Z, Li M, Zhang S, Miao Y, Guan W, Liu G, Yan L, De Saeger S, Song S

Estrogen receptor ? (ER?) and NOD-like receptor family pyrin domain containing 6 (NLRP6) are highly expressed in intestinal tissues. Loss of ER? and NLRP6 exacerbate colitis in mouse models; however, the underlying mechanisms are incompletely understood. Here, we report that ER? directly activates the NLRP6 gene expression via binding to estrogen responsive element of Nlrp6 gene promoter. ER? also physically ... [more]

Cell Rep Oct. 11, 2022; 41(2);111454 [Pubmed: 36223738]

Throughput

  • Low Throughput

Curated By

  • BioGRID