BAIT

ASXL3

BRPS, KIAA1713
additional sex combs like transcriptional regulator 3
Autism spectrum disorder (ASD) Project
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

KPNA2

IPOA1, QIP2, RCH1, SRP1alpha
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer.

Tsuboyama N, Szczepanski AP, Zhao Z, Wang L

BRCA1-associated protein 1 (BAP1) is an ubiquitin carboxy-terminal hydrolase, which forms a multi-protein complex with different epigenetic factors, such as ASXL1-3 and FOXK1/2. At the chromatin level, BAP1 catalyzes the removal of mono-ubiquitination on histone H2AK119 in collaboration with other subunits within the complex and functions as a transcriptional activator in mammalian cells. However, the crosstalk between different subunits and ... [more]

Genome Biol Sep. 30, 2022; 23(1);206 [Pubmed: 36180891]

Throughput

  • Low Throughput

Curated By

  • BioGRID