BAIT

ASXL2

ASXH2

additional sex combs like transcriptional regulator 2

GO Process (3)

GO Function (1)

GO Component (1)

Gene Ontology Biological Process

positive regulation of fat cell differentiation [IDA]

positive regulation of peroxisome proliferator activated receptor signaling pathway [IDA]

positive regulation of transcription from RNA polymerase II promoter [IDA]

Gene Ontology Molecular Function

peroxisome proliferator activated receptor binding [IDA]

Gene Ontology Cellular Component

nucleoplasm [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

PRPS1

ARTS, CMTX5, DFN2, DFNX1, PPRibP, PRS-I, PRSI, RP11-540N4.1

phosphoribosyl pyrophosphate synthetase 1

GO Process (9)

GO Function (3)

GO Component (1)

Gene Ontology Biological Process

5-phosphoribose 1-diphosphate biosynthetic process [TAS]

carbohydrate metabolic process [TAS]

hypoxanthine biosynthetic process [IMP]

nervous system development [IMP]

purine nucleobase metabolic process [IMP]

purine nucleotide biosynthetic process [IMP]

pyrimidine nucleotide biosynthetic process [NAS]

small molecule metabolic process [TAS]

urate biosynthetic process [IMP]

Gene Ontology Molecular Function

ATP binding [IDA]
protein homodimerization activity [IPI]
ribose phosphate diphosphokinase activity [EXP, IDA, IMP]

Gene Ontology Cellular Component

CRISPR Database HGNC Alliance of Genome Resources OMIM VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer.

Tsuboyama N, Szczepanski AP, Zhao Z, Wang L

BRCA1-associated protein 1 (BAP1) is an ubiquitin carboxy-terminal hydrolase, which forms a multi-protein complex with different epigenetic factors, such as ASXL1-3 and FOXK1/2. At the chromatin level, BAP1 catalyzes the removal of mono-ubiquitination on histone H2AK119 in collaboration with other subunits within the complex and functions as a transcriptional activator in mammalian cells. However, the crosstalk between different subunits and ... [more]

Genome Biol Sep. 30, 2022; 23(1);206 [Pubmed: 36180891]

Throughput

Low Throughput

Curated By

BioGRID