BAIT
STAU1
PPP1R150, STAU, RP3-470L14.2
staufen double-stranded RNA binding protein 1
GO Process (2)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
USP16
UBP-M, UBPM, MSTP039
ubiquitin specific peptidase 16
GO Process (13)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- cell cycle [TAS]
- cellular response to DNA damage stimulus [IDA]
- histone H2A K63-linked deubiquitination [IMP]
- histone deubiquitination [IDA]
- mitotic nuclear division [IDA]
- monoubiquitinated histone H2A deubiquitination [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of translational elongation [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein homotetramerization [IPI]
- regulation of proteasomal protein catabolic process [IBA]
- regulation of transcription from RNA polymerase II promoter [ISS]
Gene Ontology Molecular Function
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.
Cancer development is regulated by inflammation. Staufen1 (STAU1) is an RNA-binding protein whose expression level is critical in cancer cells as it is related to cell proliferation or cell death. STAU1 protein levels are downregulated during mitosis due to its degradation by the E3 ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C). In this paper, we map the molecular determinant involved in STAU1 ... [more]
Int J Mol Sci Sep. 30, 2022; 23(19); [Pubmed: 36232890]
Throughput
- High Throughput
Additional Notes
- Proximity label-MS was carried out to identify high confidence protein interactors with a total spectrum count of greater than or equal to four times over control
Curated By
- BioGRID