BAIT
STAU1
PPP1R150, STAU, RP3-470L14.2
staufen double-stranded RNA binding protein 1
GO Process (2)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MED1
CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2
mediator complex subunit 1
GO Process (32)
GO Function (20)
GO Component (5)
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [IDA]
- androgen biosynthetic process [IMP]
- androgen receptor signaling pathway [IDA]
- angiogenesis [ISS]
- cell morphogenesis [IMP]
- cellular lipid metabolic process [TAS]
- cellular response to epidermal growth factor stimulus [IDA]
- cellular response to steroid hormone stimulus [IDA]
- cellular response to thyroid hormone stimulus [IDA]
- erythrocyte development [ISS]
- fat cell differentiation [IDA]
- gene expression [TAS]
- intracellular steroid hormone receptor signaling pathway [IDA]
- keratinocyte differentiation [IMP]
- lens development in camera-type eye [ISS]
- mRNA transcription from RNA polymerase II promoter [ISS]
- megakaryocyte development [ISS]
- negative regulation of apoptotic process [ISS]
- negative regulation of keratinocyte proliferation [IMP]
- negative regulation of neuron differentiation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of gene expression [IDA, IMP]
- positive regulation of keratinocyte differentiation [IMP]
- positive regulation of receptor activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of RNA biosynthetic process [IMP]
- regulation of cell cycle [NAS]
- regulation of transcription from RNA polymerase I promoter [IDA]
- small molecule metabolic process [TAS]
- thyroid hormone mediated signaling pathway [IMP]
- transcription initiation from RNA polymerase II promoter [IDA, TAS]
Gene Ontology Molecular Function- LBD domain binding [IPI]
- RNA polymerase II transcription cofactor activity [IDA]
- chromatin binding [IMP]
- core promoter binding [IDA]
- estrogen receptor binding [IPI]
- ligand-dependent nuclear receptor binding [IDA, IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IMP, NAS]
- mediator complex binding [IDA]
- nuclear hormone receptor binding [IPI]
- peroxisome proliferator activated receptor binding [IPI]
- protein binding [IPI]
- receptor activity [IDA]
- retinoic acid receptor binding [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISS]
- thyroid hormone receptor binding [IDA, IPI]
- thyroid hormone receptor coactivator activity [IMP]
- transcription coactivator activity [IDA, IMP]
- transcription cofactor activity [IDA]
- transcription factor binding [IPI]
- vitamin D receptor binding [IPI, NAS, TAS]
- LBD domain binding [IPI]
- RNA polymerase II transcription cofactor activity [IDA]
- chromatin binding [IMP]
- core promoter binding [IDA]
- estrogen receptor binding [IPI]
- ligand-dependent nuclear receptor binding [IDA, IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IMP, NAS]
- mediator complex binding [IDA]
- nuclear hormone receptor binding [IPI]
- peroxisome proliferator activated receptor binding [IPI]
- protein binding [IPI]
- receptor activity [IDA]
- retinoic acid receptor binding [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISS]
- thyroid hormone receptor binding [IDA, IPI]
- thyroid hormone receptor coactivator activity [IMP]
- transcription coactivator activity [IDA, IMP]
- transcription cofactor activity [IDA]
- transcription factor binding [IPI]
- vitamin D receptor binding [IPI, NAS, TAS]
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.
Cancer development is regulated by inflammation. Staufen1 (STAU1) is an RNA-binding protein whose expression level is critical in cancer cells as it is related to cell proliferation or cell death. STAU1 protein levels are downregulated during mitosis due to its degradation by the E3 ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C). In this paper, we map the molecular determinant involved in STAU1 ... [more]
Int J Mol Sci Sep. 30, 2022; 23(19); [Pubmed: 36232890]
Throughput
- High Throughput
Additional Notes
- Proximity label-MS was carried out to identify high confidence protein interactors with a total spectrum count of greater than or equal to four times over control
Curated By
- BioGRID