BAIT

STAU1

PPP1R150, STAU, RP3-470L14.2
staufen double-stranded RNA binding protein 1
Homo sapiens
PREY

SMAP2

SMAP1L, RP1-228H13.3
small ArfGAP2
GO Process (0)
GO Function (0)
GO Component (2)

Gene Ontology Cellular Component

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

Gonzalez Quesada Y, DesGroseillers L

Cancer development is regulated by inflammation. Staufen1 (STAU1) is an RNA-binding protein whose expression level is critical in cancer cells as it is related to cell proliferation or cell death. STAU1 protein levels are downregulated during mitosis due to its degradation by the E3 ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C). In this paper, we map the molecular determinant involved in STAU1 ... [more]

Int J Mol Sci Sep. 30, 2022; 23(19); [Pubmed: 36232890]

Throughput

  • High Throughput

Additional Notes

  • Proximity label-MS was carried out to identify high confidence protein interactors with a total spectrum count of greater than or equal to four times over control

Curated By

  • BioGRID