BAIT
STAU1
PPP1R150, STAU, RP3-470L14.2
staufen double-stranded RNA binding protein 1
GO Process (2)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MTRR
MSR, cblE
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
GO Process (12)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- DNA methylation [ISS]
- cellular nitrogen compound metabolic process [TAS]
- cobalamin metabolic process [TAS]
- folic acid metabolic process [ISS]
- methionine metabolic process [TAS]
- methylation [TAS]
- oxidation-reduction process [TAS]
- small molecule metabolic process [TAS]
- sulfur amino acid metabolic process [TAS]
- vitamin metabolic process [TAS]
- water-soluble vitamin metabolic process [TAS]
- xenobiotic metabolic process [TAS]
Gene Ontology Molecular Function- FMN binding [TAS]
- NADP binding [TAS]
- NADPH-hemoprotein reductase activity [IBA]
- [methionine synthase] reductase activity [TAS]
- flavin adenine dinucleotide binding [IDA, TAS]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [IBA]
- oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [IDA]
- FMN binding [TAS]
- NADP binding [TAS]
- NADPH-hemoprotein reductase activity [IBA]
- [methionine synthase] reductase activity [TAS]
- flavin adenine dinucleotide binding [IDA, TAS]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [IBA]
- oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [IDA]
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.
Cancer development is regulated by inflammation. Staufen1 (STAU1) is an RNA-binding protein whose expression level is critical in cancer cells as it is related to cell proliferation or cell death. STAU1 protein levels are downregulated during mitosis due to its degradation by the E3 ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C). In this paper, we map the molecular determinant involved in STAU1 ... [more]
Int J Mol Sci Sep. 30, 2022; 23(19); [Pubmed: 36232890]
Throughput
- High Throughput
Additional Notes
- Proximity label-MS was carried out to identify high confidence protein interactors with a total spectrum count of greater than or equal to four times over control
Curated By
- BioGRID