BAIT
STAU1
PPP1R150, STAU, RP3-470L14.2
staufen double-stranded RNA binding protein 1
GO Process (2)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EGLN1
C1orf12, ECYT3, HIF-PH2, HIFPH2, HPH-2, HPH2, PHD2, SM20, ZMYND6, PNAS-118
egl-9 family hypoxia-inducible factor 1
GO Process (10)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- cellular response to hypoxia [TAS]
- negative regulation of cAMP catabolic process [ISS]
- negative regulation of cyclic-nucleotide phosphodiesterase activity [ISS]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- oxygen homeostasis [IDA]
- peptidyl-proline hydroxylation to 4-hydroxy-L-proline [IDA]
- regulation of angiogenesis [ISS]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- response to hypoxia [IDA]
- response to nitric oxide [IDA]
Gene Ontology Molecular Function- enzyme binding [ISS]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [IDA]
- peptidyl-proline 4-dioxygenase activity [IDA]
- peptidyl-proline dioxygenase activity [TAS]
- protein binding [IPI]
- enzyme binding [ISS]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [IDA]
- peptidyl-proline 4-dioxygenase activity [IDA]
- peptidyl-proline dioxygenase activity [TAS]
- protein binding [IPI]
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.
Cancer development is regulated by inflammation. Staufen1 (STAU1) is an RNA-binding protein whose expression level is critical in cancer cells as it is related to cell proliferation or cell death. STAU1 protein levels are downregulated during mitosis due to its degradation by the E3 ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C). In this paper, we map the molecular determinant involved in STAU1 ... [more]
Int J Mol Sci Sep. 30, 2022; 23(19); [Pubmed: 36232890]
Throughput
- High Throughput
Additional Notes
- Proximity label-MS was carried out to identify high confidence protein interactors with a total spectrum count of greater than or equal to four times over control
Curated By
- BioGRID