BAIT
STAU1
PPP1R150, STAU, RP3-470L14.2
staufen double-stranded RNA binding protein 1
GO Process (2)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
INO80
INO80A, INOC1, hINO80
INO80 complex subunit
GO Process (14)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- DNA duplex unwinding [IDA]
- UV-damage excision repair [IMP]
- cellular response to UV [IMP]
- cellular response to ionizing radiation [IMP]
- chromatin remodeling [IDA]
- double-strand break repair [IMP]
- double-strand break repair via homologous recombination [IMP]
- mitotic sister chromatid segregation [IMP]
- positive regulation of cell growth [IMP]
- positive regulation of nuclear cell cycle DNA replication [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of G1/S transition of mitotic cell cycle [IMP]
- spindle assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.
Cancer development is regulated by inflammation. Staufen1 (STAU1) is an RNA-binding protein whose expression level is critical in cancer cells as it is related to cell proliferation or cell death. STAU1 protein levels are downregulated during mitosis due to its degradation by the E3 ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C). In this paper, we map the molecular determinant involved in STAU1 ... [more]
Int J Mol Sci Sep. 30, 2022; 23(19); [Pubmed: 36232890]
Throughput
- High Throughput
Additional Notes
- Proximity label-MS was carried out to identify high confidence protein interactors with a total spectrum count of greater than or equal to four times over control
Curated By
- BioGRID