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BAIT

ASXL2

ASXH2

additional sex combs like transcriptional regulator 2

GO Process (3)

GO Function (1)

GO Component (1)

Gene Ontology Biological Process

positive regulation of fat cell differentiation [IDA]

positive regulation of peroxisome proliferator activated receptor signaling pathway [IDA]

positive regulation of transcription from RNA polymerase II promoter [IDA]

Gene Ontology Molecular Function

peroxisome proliferator activated receptor binding [IDA]

Gene Ontology Cellular Component

nucleoplasm [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

EEF1A1

CCS-3, CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, GRAF-1EF, HNGC:16303, LENG7, PTI1, eEF1A-1, RP11-505P4.2

eukaryotic translation elongation factor 1 alpha 1

GO Process (5)

GO Function (5)

GO Component (8)

Gene Ontology Biological Process

cellular protein metabolic process [TAS]

cellular response to epidermal growth factor stimulus [IDA]

gene expression [TAS]

translation [TAS]

translational elongation [TAS]

Gene Ontology Molecular Function

GTP binding [TAS]
poly(A) RNA binding [IDA]
protein binding [IPI]
protein kinase binding [IPI]
translation elongation factor activity [TAS]

Gene Ontology Cellular Component

cytoplasm [IDA, ISS, TAS]

eukaryotic translation elongation factor 1 complex [TAS]

extracellular space [IDA]

extracellular vesicular exosome [IDA]

nucleolus [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer.

Tsuboyama N, Szczepanski AP, Zhao Z, Wang L

BRCA1-associated protein 1 (BAP1) is an ubiquitin carboxy-terminal hydrolase, which forms a multi-protein complex with different epigenetic factors, such as ASXL1-3 and FOXK1/2. At the chromatin level, BAP1 catalyzes the removal of mono-ubiquitination on histone H2AK119 in collaboration with other subunits within the complex and functions as a transcriptional activator in mammalian cells. However, the crosstalk between different subunits and ... [more]

Genome Biol Sep. 30, 2022; 23(1);206 [Pubmed: 36180891]

Throughput

Low Throughput

Curated By

BioGRID