An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer.

Tsuboyama N, Szczepanski AP, Zhao Z, Wang L

BRCA1-associated protein 1 (BAP1) is an ubiquitin carboxy-terminal hydrolase, which forms a multi-protein complex with different epigenetic factors, such as ASXL1-3 and FOXK1/2. At the chromatin level, BAP1 catalyzes the removal of mono-ubiquitination on histone H2AK119 in collaboration with other subunits within the complex and functions as a transcriptional activator in mammalian cells. However, the crosstalk between different subunits and ... [more]

Genome Biol Sep. 30, 2022; 23(1);206 [Pubmed: 36180891]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

ASXL2

Gene Ontology Biological Process

Gene Ontology Molecular Function

peroxisome proliferator activated receptor binding [IDA]

Gene Ontology Cellular Component

CAPZA2