GAP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DAL81
Gene Ontology Biological Process
Gene Ontology Molecular Function- RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly [IDA, IMP]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IMP, IPI]
- RNA polymerase II transcription factor recruiting transcription factor activity [IDA, IMP]
- RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly [IDA, IMP]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IMP, IPI]
- RNA polymerase II transcription factor recruiting transcription factor activity [IDA, IMP]
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Amino acid signaling in yeast: post-genome duplication divergence of the Stp1 and Stp2 transcription factors.
When yeast cells detect external amino acids via their permease-like Ssy1 sensor, the cytosolic precursor forms of Stp1 and Stp2 transcription factors are activated by endoproteolytic removal of their N-terminal domains, a reaction catalyzed by the Ssy5 endoprotease. The processed Stp factors then migrate into the nucleus, where they activate transcription of several amino acid permease genes including AGP1. We ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- GAP1/STP1/UGA35 triple mutants are inviable
- genetic complex
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GAP1 DAL81 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 426382 | |
| GAP1 DAL81 | Positive Genetic Positive Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores. | High | 0.2096 | BioGRID | 1910924 | |
| DAL81 GAP1 | Positive Genetic Positive Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores. | High | 0.1782 | BioGRID | 1909236 | |
| GAP1 DAL81 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 426380 |
Curated By
- BioGRID