Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

MAEL facilitates metabolic reprogramming and breast cancer progression by promoting the degradation of citrate synthase and fumarate hydratase via chaperone-mediated autophagy.

Zhou L, Ou S, Liang T, Li M, Xiao P, Cheng J, Zhou J, Yuan L

Metabolic reprogramming is a hallmark of cancer. Several studies have shown that inactivation of Krebs cycle enzymes, such as citrate synthase (CS) and fumarate hydratase (FH), facilitates aerobic glycolysis and cancer progression. MAEL has been shown to play an oncogenic role in bladder, liver, colon, and gastric cancers, but its role in breast cancer and metabolism is still unknown. Here, ... [more]

FEBS J Mar. 03, 2023; (); [Pubmed: 36866961]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

FH

Gene Ontology Biological Process

Gene Ontology Molecular Function

fumarate hydratase activity [EXP]

Gene Ontology Cellular Component

LAMP2