BAIT
KDM1A
1810043O07Rik, AA408884, Aof2, D4Ertd478e, Kdm1, Lsd1, mKIAA0601, RP23-426N4.2
lysine (K)-specific demethylase 1A
GO Process (31)
GO Function (18)
GO Component (4)
Gene Ontology Biological Process
- cell proliferation [IMP]
- chromatin organization involved in regulation of transcription [IC]
- granulocyte differentiation [IMP]
- guanine metabolic process [ISO]
- histone H3-K4 demethylation [ISO]
- histone H3-K9 demethylation [IMP, ISO]
- in utero embryonic development [IMP]
- muscle cell development [IMP]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [ISO]
- negative regulation of histone H3-K4 methylation [IMP]
- negative regulation of histone H3-K9 methylation [IMP]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- oxidation-reduction process [ISO]
- pituitary gland development [IMP]
- positive regulation of cell size [ISO]
- positive regulation of chromatin binding [ISO]
- positive regulation of erythrocyte differentiation [IMP]
- positive regulation of hormone biosynthetic process [IMP]
- positive regulation of megakaryocyte differentiation [IMP]
- positive regulation of neural precursor cell proliferation [IMP]
- positive regulation of neuron projection development [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of stem cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- protein demethylation [ISO]
- regulation of primitive erythrocyte differentiation [IMP]
- regulation of transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- MRF binding [IPI, ISO]
- RNA polymerase II transcription factor binding [IPI]
- androgen receptor binding [ISO]
- chromatin binding [ISO]
- demethylase activity [ISO]
- enzyme binding [IPI, ISO]
- flavin adenine dinucleotide binding [ISO]
- histone demethylase activity [ISO]
- histone demethylase activity (H3-K4 specific) [ISO]
- histone demethylase activity (H3-K9 specific) [ISO]
- histone demethylase activity (H3-dimethyl-K4 specific) [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- oxidoreductase activity [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [IDA]
- MRF binding [IPI, ISO]
- RNA polymerase II transcription factor binding [IPI]
- androgen receptor binding [ISO]
- chromatin binding [ISO]
- demethylase activity [ISO]
- enzyme binding [IPI, ISO]
- flavin adenine dinucleotide binding [ISO]
- histone demethylase activity [ISO]
- histone demethylase activity (H3-K4 specific) [ISO]
- histone demethylase activity (H3-K9 specific) [ISO]
- histone demethylase activity (H3-dimethyl-K4 specific) [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- oxidoreductase activity [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Mus musculus
PREY
PLEC
AA591047, AU042537, EBS1, PCN, PLTN, Plec1
plectin
GO Process (2)
GO Function (7)
GO Component (11)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.
Lysine specific demethylase 1 (LSD1) regulates gene expression as part of the CoREST complex, along with co-repressor of REST (CoREST) and histone deacetylase 1 (HDAC1). CoREST is recruited to specific genomic loci by core components and numerous transient interactions with chromatin-associated factors and transcription factors. We hypothesise that many of these weaker and transient associations may be difficult to identify ... [more]
Mol Omics Jan. 17, 2022; 18(1);31-44 [Pubmed: 34709266]
Throughput
- High Throughput
Additional Notes
- (24 hour time point)
- BioID
- LSD1 interaction in mouse embryonic stem cells treated with retinoic acid (RA) to stimulate ES cell differentiation.
Curated By
- BioGRID