An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

ARHGAP24 represses ?-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.

Yang W, Wang B, Yu Q, Liu T, Li T, Tian T, Jin A, Ding L, Chen W, Wang H, Xian J, Pan B, Zhou J, Fan J, Yang X, Guo W

Rationale: Accumulating evidence shows that Rho-GTPase-activating proteins (RhoGAPs) exert suppressive roles in cancer cell proliferation and metastasis. However, no study has systematically investigated the clinical significance of RhoGAPs and analyzed the functions of ARHGAP24 in hepatocellular carcinoma (HCC). Methods: The relationship between RhoGAP expression and HCC prognosis was investigated via using The Cancer Genome Atlas and Gene Expression Omnibus databases. ... [more]

Theranostics Sep. 29, 2022; 12(14);6189-6206 [Pubmed: 36168627]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

ARHGAP24

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

CUL5