SWT1
Gene Ontology Biological Process
Gene Ontology Molecular Function
MLP1
Gene Ontology Biological Process
- negative regulation of protein import into nucleus during spindle assembly checkpoint [IGI]
- nuclear retention of unspliced pre-mRNA at the site of transcription [IGI, IMP]
- poly(A)+ mRNA export from nucleus [IMP]
- protein import into nucleus [IGI]
- protein localization to nuclear pore [IMP]
- telomere tethering at nuclear periphery [IGI]
- transcriptional activation by promoter-terminator looping [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
An endoribonuclease functionally linked to perinuclear mRNP quality control associates with the nuclear pore complexes.
Nuclear mRNA export is a crucial step in eukaryotic gene expression, which is in yeast coupled to cotranscriptional messenger ribonucleoprotein particle (mRNP) assembly and surveillance. Several surveillance systems that monitor nuclear mRNP biogenesis and export have been described, but the mechanism by which the improper mRNPs are recognized and eliminated remains poorly understood. Here we report that the conserved PIN ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: protein/peptide accumulation (APO:0000149)
Additional Notes
- mutation of swt1 increases the mRNP read-through leakage in an esc1 or mlp1 mutant
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MLP1 SWT1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1258 | BioGRID | 395958 | |
| SWT1 MLP1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2046 | BioGRID | 2184909 |
Curated By
- BioGRID